20.04 – Audio crackles when I run VirtualBox

Recently I’m having an issue for which audio crackles when I run VirtualBox in Ubuntu 20.04.
If I then execute pulseaudio -k it does fix it (upon restarting programs), but still this workaround is not great.
Sometimes (much rarely though) this also happens without opening VirtualBox, just by watching a video on Firefox.

I currently have the HWE kernel 5.8.0-59-generic #66~20.04.1-Ubuntu and my audio system is the onboard analog device as following (aplay --list-device):

card 1: Generic (HD-Audio Generic), device 0: ALC1220 Analog (ALC1220 Analog)
  Subdevices: 1/1
  Subdevice #0: subdevice #0
card 1: Generic (HD-Audio Generic), device 1: ALC1220 Digital (ALC1220 Digital)
  Subdevices: 1/1
  Subdevice #0: subdevice #0

And this is what reported by lspci -v:

10:00.4 Audio device: Advanced Micro Devices, Inc. (AMD) Starship/Matisse HD Audio Controller
    Subsystem: ASRock Incorporation Starship/Matisse HD Audio Controller
    Flags: bus master, fast devsel, latency 0, IRQ 135
    Memory at fcb00000 (32-bit, non-prefetchable) (size=32K)
    Capabilities: <access denied>
    Kernel driver in use: snd_hda_intel
    Kernel modules: snd_hda_intel

Not sure what to do next? How could I debug/investigate this further?

Thanks!