gui design – What Website UI/UX best practices are applicable in case of RWAs?

Recently, we have started a Rich Web Application (RWA) project. In the process of choosing a suitable UI framework –and also web components-, we faced with a problem; Is there any difference(s) between choosing a design pattern/approach for a RWA and for a normal website, in aspect of perspective and/or principles? If yes, what are those differences?

In other words, we have many UI frameworks in the market, many UI/UX best practices and some well-known design patterns for the web. If a solution (e.g. Bootstrap) is widely accepted and it has been used, could we consider such solution suitable for a RWA and vice versa? Basically, is it distinguishable?

Thanks in advance.