macos – What are the different startup paths in OSX?

I'm trying to track down malicious apps that start on reboot. They are not in System Preferences> Users and Groups> Login Items and the auto-start in-app settings are also disabled for them. I found her here:

~ / Library / LaunchAgents
/ Library / LaunchAgents
/ Library / LaunchDaemons
/ System / Library / LaunchAgents
/ System / Library / LaunchDaemons

What does each folder mean? Does removing the file simply mean that the operating system can not find it at startup?