magento2 – Product saving/data issue, including images role in 2.4.2-p1

We have a strange issue that happend with our Magento 2.4.2-p1 store.

When we create a new product and for example enter the product name and then save the product, we get the successfully save message, but the product name remains empty. So the value will not be saved. The SKU field is saved correctly and remains.

Also when we upload a product image and select all 4 image roles, like Base, Small, Swatch and Thumbnail and then save the product again. The images is saved, but only the Swatch role remains selected. All other 3 options are unselected.

In both cases when we resave the product, it does not save the issue.

Any idea how to debug this?