memory – Would it be more beneficial to run apps on a separate User Account or create profiles within an app?

I am somewhat turning my MacBook Pro into an Apple TV alternate. Considering macOS’s Fast User Switching, I was wondering if it might be more beneficial, in terms of CPU/RAM, to dedicate certain apps and extensions to separate User Account(s) and creating a shortcut within an app (BetterTouchTools) that allows you to completely customize inputs from various peripheries on a per-app basis OR creating separate Presets within the app on my main User Account and assigning a shortcut to switch between the various Preset (read: scenarios).

PS BTT allows for some deeps customization of the Siri Remote on macOS.