This ?
Plot[x^2, {x, -10, 10},
PlotLabel ->
Row[{Style["The top line should be bold and blackn", Black, Bold,
15], Style[
"The bottom line should be a smaller font, black, and normal",
Black], 12}],
TicksStyle -> {Directive["Label", 10, Black, Thick],
Directive["Label", 12, Black, Bold]}]