SharePoint 2016 Backup – SharePoint Stack Exchange

We have SP2016 Topology 2 servers for each
2 APP Servers
2 DC Servers
2 FE Servers
2 SC Servers
1 SQL Server

This Farm never have Back UP before and I would like to perform backup for the first time, My question is Can I perform Backup from CA and does it make any difference from which server or servers I need
to perform the Backup and if I need to restore do I need to restore from the same server.
or is it better to use PowerShell.
Also do I need to backup IIS setting?
what is the best practice?